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The idea that sticky brain plaques cause Alzheimer’s disease began as an interesting hypothesis and eventually became drug industry dogma. Now, after a string of clinical trial failures, that hypothesis looks less credible than ever. 

Raymond J. Tesi STAT News April 30, 2019

Aducanumab's failure puts pressure on field to look beyond amyloid

Ned Pagliarulo March 22, 2019

After amyloid failures, it’s time to take a new tack for treating Alzheimer’s